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Bailey S. Rose
Ph.D. Vanderbilt University
Education
Ph.D., Chemistry
Vanderbilt University
Nashville, TN
2022 - 2017
- Dissertation: Improving Untargeted Molecular Annotation Using Structurally-Specific Ion Mobility-Mass Spectrometry
- John A. McLean Research Group
B.S., Chemistry
Belmont University
Nashville, TN
2017 - 2013
- Mathematics minor
- Magna Cum Laude
Research Experience
Graduate Research Assistant
McLean Laboratory
Vanderbilt University
2022 - 2017
- Explored strategies for improving lipid and metabolite identifications in untargeted -omics studies using ion mobility-derived collision cross sections (CCS). Developed standardization and reporting recommendations for CCS values derived from various types of ion mobility measurements and used these recommendations to build databases and implement novel algorithms for obtaining high-confidence molecular identifications. Other projects included LC-MS/MS method optimization for lipidomics and application of lipidomic methodology and data analysis pipelines to various biological systems in collaboration with the Center for Innovative Technology at Vanderbilt.
Undergraduate Researcher
Spence Laboratory
Belmont University
2017 - 2016
- Alignment and completion of the optical set up of a cavity ring-down spectroscopy instrument.
Undergraduate Researcher
Stace Laboratory
Belmont University
2016 - 2015
- Synthesis and characterization of an enzyme-mimic copper(II) Schiff-base complex. Exploration of the kinetics of its reaction with oxalic acid using spectroscopic methods.
Industry Experience
Analytical Chemist Summer Intern
Carlisle Construction Materials
Carlisle, PA
2016
- Completed analytical projects relating to production quality control and warranty claims. Developed rheological methods and SOPs for new product lines in development, and trained staff on use and maintenance of the rheometer.
Teaching Experience
Graduate Teaching Assistant
Vanderbilt Chemistry Department
Nashville, TN
2021 - 2017
- General Chemistry Lab, Analytical Chemistry Lab, and Capstone Advanced Integrated Lab
Publications
A Collision Cross Section Calibration Strategy for Lipid Measurements in SLIM-based High Resolution Ion Mobility
Rose, B. S.; May, J. C.; Reardon, A. R.; McLean, J. A.
N/A
2022
- Journal of the American Society for Mass Spectrometry
Improving confidence in lipidomic annotations by incorporating empirical ion mobility regression analysis and chemical class prediction
Rose, B. S.; May, J. C.; Picache, J. A.; Codreanu, S. G.; Sherrod, S. D.; McLean, J. A.
N/A
2022
- Bioinformatics
- DOI: 10.1093/bioinformatics/btac197
High confidence shotgun lipidomics using structurally selective ion mobility-mass spectrometry
Rose, B. S.; Leaptrot, K. L.; Harris, R. A.; Sherrod, S. D.; May, J. C.; McLean, J. A.
N/A
2021
- Shotgun Lipidomics: Methods and Protocols
- DOI: 10.1007/978-1-0716-1410-5_2
Resolving Power and Collision Cross Section Measurement Accuracy of a Prototype High-Resolution Ion Mobility Platform Incorporating Structures for Lossless Ion Manipulation
May, J. C.; Leaptrot, K. L.; Rose, B. S.; Moser, K. L. M.; Deng, L.; Maxon, L.; DeBord, D.; McLean, J. A.
N/A
2021
- Journal of the American Society for Mass Spectrometry
- DOI: 10.1021/jasms.1c00056
Collision cross section compendium to filter and predict multi-omic compound identities.
Picache, J. A.; Rose, B. S.; Balinski, A.; Leaptrot, K. L.; Sherrod, S. D.; May, J. C.; McLean, J. A.
N/A
2019
- Chemical Science
- DOI: 10.1039/c8sc04396e
Untargeted molecular discovery in primary metabolism: collision cross section as a molecular descriptor in ion mobility-mass spectrometry
Nichols, C. M., Dodds, J. N.; Rose, B. S.; Picache, J. A., Morris, C. M.; May, J. C., Sherrod, S. D., McLean, J. A.
N/A
2018
- Analytical Chemistry
- DOI: 10.1021/acs.analchem.8b04322
Presentations
Structural Characterization of Previously Unresolved Lipids with HRIM-Mass Spectrometry
Rose, B. S., Reardon, A. R., Leaptrot, K. L., May, J. C., McLean, J. A.
N/A
2022
- MOBILion Systems Technical Breakfast Seminar at ASMS. Minneapolis, MN
- Invited oral presentation
Structural Characterization of Previously Unresolved Lipids with HRIM-Mass Spectrometry
Rose, B. S., Reardon, A. R., Leaptrot, K. L., May, J. C., McLean, J. A.
N/A
2022
- 70th Annual Conference for the American Society of Mass Spectrometry and Allied Topics. Minneapolis, MN
- Poster presentation
Lipid Collision Cross Section Calibration Strategies for High Resolution SLIM-based Traveling Wave Ion Mobility Separations
Rose, B. S., Leaptrot, K. L., Reardon, A. R., May, J. C., McLean, J. A.
N/A
2021
- 69th Annual Conference for the American Society of Mass Spectrometry and Allied Topics. Philadelphia, PA
- Poster presentation
Lipid Isomer Separations via a High Resolution Prototype SLIM-based Ion Mobility Instrument in Support of High Confidence Lipidomics
Leaptrot, K. L., Rose, B. S., Wormwood, K. L. M., May, J. C., McLean, J. A.
N/A
2020
- VICB Student Research Symposium. Nashville, TN
- Poster presentation
Collision cross section calibration strategies for a prototype SLIM-based ion mobility instrument
Rose, B. S., Leaptrot, K. L., Wormwood, K. L. M., May, J. C., McLean, J. A.
N/A
2020
- Annual Conference for the American Society of Mass Spectrometry and Allied Topics “Reboot”
- Poster presentation
Achieving a Consistent and Unified Community-wide Molecular Database: The Collision Cross Section Compendium
Rose, B. S., Picache, J. A., May, J. C., McLean, J. A.
N/A
2019
- 1st Annual Agilent North American Ion Mobility Workshop. Raleigh, NC.
- Invited oral presentation
Integrated multidimensional liquid chromatography-ion mobility-tandem mass spectrometry (LC-IM-MS/MS) workflow for high-confidence annotations in untargeted lipidomics
Rose, B. S.; Codreanu, S. G., May, J. C., Sherrod, S. D., McLean, J. A.
N/A
2019
- 67th Annual Conference for the American Society of Mass Spectrometry and Allied Topics. Atlanta, GA.
- Oral presentation
Development of a LC-IM-MS/MS workflow for high confidence lipidomics
Rose, B. S.; Codreanu, S. G.; May, J. C., Sherrod, S. D., McLean, J. A
N/A
2018
- Southeastern Lipid Research Conference. Nashville, TN.
- Poster presentation
Awards and recognition
ASMS Student Travel Award
American Society for Mass Spectrometry
N/A
2020
Student Travel Award
May Institute for Computational Statistics in Mass Spectrometry
N/A
2019
VICB Research Fellowship
Vanderbilt Institute of Chemical Biology
N/A
2018
Mitchum E. Warren Fellowship
Vanderbilt Chemistry Department
N/A
2017